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ea0015oc18 | Tumours, diabetes, bone | SFEBES2008

Human omental adipose tissue as a key site for the inflammatory 15-lipoxygenase pathway: Implications for metabolic disease

Hill Margaret J , McTernan Philip G , da Silva Nancy F , McGee Kirsty C , Kusminski Christine M , Baker Adam R , Kumar Sudhesh , Harte Alison L

Materials and methods: Paired AbSc and Om AT were collected from patients undergoing elective liposuction surgery (Age; 45±1.72 years; lean BMI; 22.91±0.56 kg/m2; obese BMI; 33.51±1.04 kg/m2; n=23) for gene expression analysis by microarray and real time polymerase chain reaction (PCR). Fasted blood was taken to measure metabolic parameters.Results: Microarray data showed that Om AT had signi...

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ea0013p183 | Diabetes, metabolism and cardiovascular | SFEBES2007

Depot-specific activity of NFκB and JNK in human abdominal subcutaneous and omental adipose tissue

da Silva Nancy F , Fowler Anne E , Harte Alison L , Baker Adam R , Kusminski Christine M , Creely Steven J , Starcynski Jane , O’Hare Joseph P , Kumar Sudhesh , McTernan Philip G

Central obesity is strongly associated with sub-clinical inflammation, insulin resistance (IR) and type 2 diabetes mellitus (T2DM), but the intracellular mechanisms involved in the pathogenesis of central obesity remain unclear. Recent studies have implicated NFκB and c-jun N terminal kinase (JNK) as central molecules linking insulin action and inflammation in mice. As such we examined (1) the inflammatory intracellular signaling pathways involving NFκB, JNK as a pot...

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Endocrine Abstracts

Human omental adipose tissue as a key site for the inflammatory 15-lipoxygenase pathway: Implications for metabolic disease

Depot-specific activity of NFκB and JNK in human abdominal subcutaneous and omental adipose tissue

BiosciAbstracts